Spain was one of the first European countries to be affected after Italy, with the outbreak estimated to have started in February 2020.

The epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing COVID-19, has spread rapidly around the globe ( 1). Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified. Respiratory symptoms were not increased during the COVID-19 period.Ĭonclusion: The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. 11.1%), and more myocardial dysfunction (30.8 vs. 505 pg/ml), less aneurysm development (3.8 vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 423 × 10 9/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 29%), had incomplete KD presentation (73 vs. CoV+ patients were significantly older (7.5 vs. There was a significant increase in cases and PICU admissions in 2020 ( P-trend = 0.001 and 0.0004, respectively). Results: One hundred and twenty-four cases were collected. We compared the KD cases diagnosed during the COVID-19 period (March 1–May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV–) to those from the same period during 20 (PreCoV). Material and Methods: Medical data of KD patients from Januuntil was collected from the KAWA-RACE study group. This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). Introduction: COVID-19 has a less severe course in children.

16Department of Pediatrics, Hospital Regional Universitario de Málaga, Málaga, Spain.

15Department of Pediatrics, Hospital Universitario Puerta Del Mar de Cádiz, Cádiz, Spain.14Department of Pediatrics, Hospital Universitario de Donostia, Guipuzcoa, Spain.13Department of Pediatrics, Hospital Universitario Materno-Infantil de Las Palmas de Gran Canaria, Canarias, Spain.12Pediatric Infectious Disease Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, Zaragoza, Spain.11Pediatric Cardiology Unit, Department of Pediatrics, Hospital Universitario Vall d'Hebron Barcelona, Barcelona, Spain.10Department of Pediatrics, Hospital Universitario y Politécnico La Fe, Valencia, Spain.9Department of Pediatrics, Hospital Universitario Gregorio Marañón, Madrid, Spain.8Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Department of Pediatrics, Hospital Virgen del Rocío, Sevilla, Spain.7Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.6Department of Pediatrics, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.5Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona, Barcelona, Spain.4Department of Pediatrics, Hospital Universitario Infanta Sofia, Madrid, Spain.3Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain.2Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.1Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.Grasa 3 † Sara Domínguez-Rodríguez 2 Ana Barrios Tascón 4 Judith Sánchez-Manubens 5 Jordi Anton 5 Beatriz Mercader 6 Enrique Villalobos 7 Marisol Camacho 8 María Luisa Navarro Gómez 9 Manuel Oltra Benavent 10 Gemma Giralt 11 Matilde Bustillo 12 Ana María Bello Naranjo 13 Beatriz Rocandio 14 Moisés Rodríguez-González 15 Esmeralda Núñez Cuadros 16 Javier Aracil Santos 3 David Moreno 16 Cristina Calvo 3 the KAWA-RACE Study Group ‡

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